This issue is devoted to examining the unique challenges facing women and girls across the world. Top academics, non-governmental workers, activists and United Nations officials write of how to address these challenges, whether they are effectively being addressed at all and, if so, what worked and why, and what did not and why not? Among the prominent contributions, including articles by Deputy Secretary-General Asha-Rose Migiro, Thoraya Obaid, Rachel Mayanja, UN Messenger of Peace Charlize Theron and UN Citizen Ambassador Emily Troutman, are essays and first-person accounts of war and sexual violence, safety of refugee women and girls and the UN system's coordinated response to protecting the rights of women and girls everywhere."