| Rank | Name (Country) | Year | Total Assets in € billion |
| 1. | Bill & Melinda Gates Foundation (WA) | $1,356,327,000 | 12/31/05 |
| 2. | Merck Patient Assistance Program, Inc. (NJ) | 519,998,639 | 12/31/04 |
| 3. | The Ford Foundation (NY) | 516,907,177 | 09/30/05 |
| 4. | The Bristol-Myers Squibb Patient Assistance Foundation, Inc. (NJ) | 506,639,972 | 12/31/04 |
| 5. | Lilly Endowment Inc. (IN) | 427,465,199 | 12/31/05 |
| 6. | The Robert Wood Johnson Foundation (NJ) | 372,500,000 | 12/31/05 |
| 7. | The William and Flora Hewlett Foundation (CA) | 319,916,093 | 12/31/05 |
| 8. | Janssen Ortho Patient Assistance Foundation, Inc. (NJ) | 289,783,393 | 12/31/04 |
| 9. | The Annenberg Foundation (PA) | 251,663,628 | 06/30/05 |
| 10. | Gordon and Betty Moore Foundation (CA) | 225,986,140 | 12/31/04 |
| 11. | W. K. Kellogg Foundation (MI) | 219,862,847 | 08/31/05 |
| 12. | The Andrew W. Mellon Foundation (NY) | 199,340,000 | 12/31/05 |
| 13. | John D. and Catherine T. MacArthur Foundation (IL) | 194,500,000 | 12/31/05 |
| 14. | The Roche Patient Assistance Foundation (NJ) | 174,463,465 | 12/31/05 |
| 15. | The Annie E. Casey Foundation (MD) | 171,354,926 | 12/31/04 |
| 16. | The Starr Foundation (NY) | 168,167,773 | 12/31/04 |
| 17. | Wal-Mart Foundation (AR) | 154,537,406 | 01/31/05 |
| 18. | The California Endowment (CA) | 153,242,789 | 02/28/05 |
| 19. | The David and Lucile Packard Foundation (CA) | 150,115,645 | 12/31/05 |
| 20. | Boehringer Ingelheim Cares Foundation, Inc. (CT) | 147,996,554 | 12/31/05 |