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Antibiotic resistance from environmental pollution
Heavy use of antibiotics in people and animals, encouraged by commercial pressures, risks causing significant antibiotic contamination of the natural environment and consequent development of resistance in communities of non-disease organisms. Such contamination of microbial communities in septic tanks, sewers, soil, receiving waters and other environmental compartments could create a widespread pool of antibiotic-resistant microbes from which resistance could be transferred back into human and animal disease organisms. The risk from widespread use of antibiotics as growth promoters in livestock is being widely debated (Coghlan, 1996; Bonner, 1997). Antibiotic and other drug resistance is already a major issue in medicine, with significant health and economic impacts, as shown by the resurgence of tuberculosis and malaria, and multiple resistance is easily developed (LeBlanc et al. 1997) What has not been appreciated is the potential of drugs as environmental pollutants to create new pools of resistance which, given the new evidence of genetic transfers across species, could accelerate the development of resistance in many disease organisms. If new forms of resistance start to come not only from human treatments and hospital settings, but by inter-species transfers from the environment, the growing ineffectiveness of present forms of treatment and a revival of major epidemics is a distinct possibility.
Industrialized countries have the highest antibiotic use, and so could be the first to see the development of environmental pools of resistance. However, with global travel and widespread commerce, drug resistance can be expected to spread steadily to all parts of the world. Developing countries might thus suffer the worst consequences because of the poor state of their health services and their inability to pay for alternatives to cheap antibiotics. Pharmaceutical companies should see that it is in their own interest to minimize drug use and pollution of the environment, since avoiding the spread of resistance will keep their medicines effective longer.
Research is urgently needed into the environmental impacts on natural microbial communities of heavy antibiotic and other drug use in medicine and agriculture/aquaculture. The scenario is plausible, but the risks cannot be estimated because of insufficient understanding. As a precautionary approach, the use of drugs/antibiotics should be reduced to the minimum necessary. In addition, drugs could be developed that break down quickly in the environment; doctors could be assisted, perhaps by expert systems, to chose medicines and to adopt treatment regimes that minimize the risk of creating or spreading resistance; waste treatment facilities that destroy drugs before they contaminate the environment should be installed in hospitals and other settings where drug use is high; and national and international legislation could be considered to prevent or limit the spread of drug resistance.
Bonner, John. 1997. "Hooked on drugs." New Scientist, 18 January 1997, p. 24-27. (also letters commenting on this article in New Scientist, 22 February 1997, p. 51.)
Coghlan, Andy. 1996. "Animal antibiotics 'threaten hospital epidemics'." New Scientist, 27 July 1996, p. 7.
LeBlanc, Donald et al. 1997. Antimicrobial Agents and Chemotherapy 41:1598.
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